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Abstract #2783

Bound Pool Fraction & T1,free Quantification by Non-Linear Parameter Identification of Composite Echoes

Bernhard Neumayer1, Rudolf Stollberger1

1Institute of Medical Engineering, Graz University of Technology, Graz, Steiermark, Austria

The method of phase acquisition of composite echoes (PACE) is used to additionally quantify BPF by applying a non-linear parameter identification and therefore gaining information on the separate components of the acquired signal. Extrapolation of the stimulated echo component for measurements with TM>100ms yields S0/(1+f) which in combination with S0 acquired using a minimum possible TM allows for quantification of the bound pool fraction BPF additionally to the T1 quantification provided by the phase information. The method was validated using BSA phantoms with concentrations ranging from 10 to 30% of BSA to water per weight and provided a linear relationship of BPF and BSA concentration.