Abstract #2789

Exchange Resolved Measurements of Extra-Cellular Volume in a Graded Muscle Edema Model

Jack T. Skinner^1,2, Todd E. Peterson^2,3, Mark D. Does^1,2

¹Biomedical Engineering, Vanderbilt University, Nashville, TN, United States; ²Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States; ³Radiology & Radiological Sciences, Vanderbilt University, Nashville, TN, United States

A simple, two-measurement method for inverting a two-pool model with water exchange is presented. T₂ measurements of injured rat skeletal muscle were made before and after contrast agent injection, from which estimates of the intrinsic extra-cellular volume fraction were computed and found to correlate strongly (R² = 0.71) with estimates derived from SPECT imaging of an extra-cellular radiotracer.