Daniel Holland1, Careesa Liu2,
Chris V. Bowen2, Andy Sederman1,
1Department of Chemical Engineering & Biotechnology, University of Cambridge, Cambridge, United Kingdom; 2Institute for Biodiagnostics (Atlantic), National Research Council Canada, Halifax, Nova Scotia, Canada
We demonstrate that the use of Compressed Sensing reconstruction of variable density spiral fMRI data minimizes the aliasing artifact inherent to sparse k-space acquisitions that can result in additional signal fluctuations in the time course data. Our data demonstrate an improvement in the apparent fMRI sensitivity relative to the same images reconstructed without CS. CS reconstruction of a 50% undersampled VD spiral acquisition resulted in a 40% increase in whole brain activation volume relative to the same data reconstructed with conventional (non-CS) techniques, demonstrating that fMRI data obtained using VD trajectories should be reconstructed using Compressed Sensing.