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Abstract #2855

Temporal Acceleration in Hyperpolarization Imaging using Image-Domain Compressed Sensing

Behzad Sharif1, Debiao Li1,2, Shawn Wagner1

1Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States; 2Northwestern University, Chicago, IL, United States

In hyperpolarization imaging, the magnetization is limited from the start of an imaging sequence and should be utilized while relaxation to thermal equilibrium occurs. Compressed sensing has been used to overcome the rapid loss of magnetization from molecules with short T1. With the introduction of molecules with longer T1, there is potential for high resolution imaging with compressed sensing used in all aspects of data acquisition. We show that high-quality images can be reconstructed from 2-fold undersampled data by exploiting the image-domain sparsity in C-13 imaging. The resulting temporal acceleration will enable higher resolution full-body imaging of hyperpolarized biomarkers for cancer detection.