Abstract #2952

Noninvasive Evaluation of Renal Oxygen Extraction Fraction Via Reduced-FOV Asymmetric Spin Echo Approach

Zhikui Xiao¹, Ajit Shankaranarayan², Emine Ulku Saritas³, Shen Hao¹, Cao Guang¹

¹Global Applied Science Laboratory, GE Healthcare, Beijing, China, People's Republic of; ²Global Applied Science Laboratory, GE Healthcare, Menlo Park, CA, United States; ³Department of Bioengineering, University of California, Berkeley, CA, United States

In this study, a 2D-RF ASE EPI sequence with flow dephasing gradient was employed to acquire images that have different susceptibility weighting. Subsequently, based on the theoretical model proposed by Yablonskiy and Haacke [4] for characterizing signal changes in the presence of deoxyhemoglobin, R2and Oxygen Extraction Fraction (OEF) were estimated from the acquired images. We show that this sequence can dynamically monitor renal function and can be used to study and treat renal disease.