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Abstract #2953

Quantitative T2* MRI for Kidneys Iron Overload Assessment in a Large Cohort of Thalassemia Major Patients.

Antonella Meloni1, Daniele De Marchi1, Vincenzo Positano1, Maria Chiara Dell'Amico1, Brunella Favilli1, Petra Keilberg1, Chiara Tudisca2, Gianluca Valeri3, Massimiliano Missere4, Angelo Zuccarelli5, Massimo Lombardi1, Alessia Pepe1

1Fondazione G.Monasterio CNR-Regione Toscana & Institute of Clinical Physiology, Pisa, Italy; 2Policlinico Paolo Giaccone, Palermo, Italy; 3Azienda Ospedaliero-Universitaria Ospedali Riuniti "Umberto I-Lancisi-Salesi", Ancona, Italy; 4Universit Cattolica del Sacro Cuore, Campobasso, Italy; 5Ospedale Civile, Olbia, Italy

Multiecho T2* MRI allows organ-specific iron overload assessment. There very few report concerning the kidneys. We studied 119 Talassemia Major patients. Systemic T2* differences between left and right kidneys were found, with significant lower values in the right one. Mean T2* value over both kidneys increased with age and did not show a significant difference amongst men ad women. Iron deposition in the kidneys was not very common in TM (36% of the patient population), but it was correlated with iron deposition in other organs (liver and heart)