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Abstract #2964

Clinical Significance of Creatine Peak in In-Vivo 1H-MR Spectroscopy of Gynecologic Tumors

Mayumi Takeuchi1, Kenji Matsuzaki1, Masafumi Harada1

1Department of Radiology, University of Tokushima, Tokushima, Japan

We evaluated 17 uterine leiomyomas and 61 ovarian tumors by 1H-MR spectroscopy at 3T. Creatine peak was observed in all 17 leiomyomas (100%), and 16 of 61 ovarian tumors (26%). The creatine concentration in leiomyomas (9.17 6.19 mM) was significantly higher than that in ovarian tumors (3.92 2.66 mM) (p<0.01). Using a cut off value of 6 mM for leiomyomas had a sensitivity of 65%, specificity of 81%, PPV of 79%, and NPV of 68%.