Abstract #2978

Investigating the Contribution of Osteoblastic Activity to ADC of Bone Metastases by Correlating Changes in ADC with Changes in T2* & HU

Christina Messiou¹, David J. Collins¹, Matthew Robson², Veronica A. Morgan¹, Catherine Simpkin¹, Diletta Bianchini³, Johann S. de Bono³, Nandita deSouza¹

¹CRUK & EPSRC Cancer Imaging Centre, Institute of Cancer Research & Royal Marsden NHS Foundation Trust, Sutton, Surrey, United Kingdom; ²Dept. of Cardiovascular Medicine, University of Oxford, Oxford, United Kingdom; ³Dept. of Medicine, Institute of Cancer Research & Royal Marsden NHS Foundation Trust, Sutton, Surrey, United Kingdom

The aim of this study was to investigate the contribution of osteoblastic activity to ADC of bone metastases from prostate carcinoma undergoing treatment by correlating changes in ADC with changes in T2* and HU. Percentage changes in ADC did not correlate with percentage change in HU or T2*. This may be because intertrabecular distance is beyond the range interrogated by the DWI technique employed in this study. Because intertrabecular distance is so large relative to cell size, a marked sclerotic response may be required to bring intratrabecular distances down to a level where it affects intercellular distances and diminishes ADC.