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Abstract #2979

Improved Diagnostic Accuracy of Whole Body Diffusion Weighted MRI using Computed Imaging.

Matthew David Blackledge1, Nina Tunariu1, David J. Collins1, Martin O. Leach1, Dow-Mu Koh1

1CR-UK & EPSRC Cancer Imaging Centre, Institute of Cancer Research & Royal Marsden Hospital, Sutton, Surrey, United Kingdom

A recent methodology known as computed diffusion weighted imaging (cDWI) has demonstrated that improved SNR may achieved at high b-values by acquiring images at multiple b-values, calculating the apparent diffusion coefficient maps and using the results to simulate the signal at a desired b-value. In the present study we compare the diagnostic utility of cDWI, computed at b-values of 1500 and 2000 s/mm2, with conventional DWI, acquired at 900 s/mm2, in a small cohort of patients diagnosed with advanced metastatic disease.