Edward Brian Welch1,2, Johan Berglund3, Joel Kullberg3, Katie Colbert Coate4, Phil Williams4, Alan Cherrington4, Malcolm J. Avison1,2
1Vanderbilt University Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States; 2Department of Radiology & Radiological Sciences, Vanderbilt University, Nashville, TN, United States; 3Department of Radiology, Uppsala University, Uppsala, Sweden; 4Department of Molecular Physiology & Biophysics, Vanderbilt University, Nashville, TN, United States
Animal models in which whole body adiposity can be manipulated and the size of specific adipose tissue (AT) depots measured longitudinally and non-invasively, can help improve our understanding of the role of specific AT depots in the pathogenesis of obesity-associated metabolic diseases. In this abstract, we describe the adaptation of a whole body fat-water MR imaging acquisition and automated analysis pipeline, initially validated in human volunteers, for whole-body FWI in dogs. We demonstrate the utility of this pipeline by following the changes in lean and AT volume in dogs placed on an obesogenic high-fat, high-fructose diet known to increase insulin.