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Abstract #3001

Longitudinal Tracking of Adiposity in a Canine Model of Insulin Resistance

Edward Brian Welch1,2, Johan Berglund3, Joel Kullberg3, Katie Colbert Coate4, Phil Williams4, Alan Cherrington4, Malcolm J. Avison1,2

1Vanderbilt University Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States; 2Department of Radiology & Radiological Sciences, Vanderbilt University, Nashville, TN, United States; 3Department of Radiology, Uppsala University, Uppsala, Sweden; 4Department of Molecular Physiology & Biophysics, Vanderbilt University, Nashville, TN, United States

Animal models in which whole body adiposity can be manipulated and the size of specific adipose tissue (AT) depots measured longitudinally and non-invasively, can help improve our understanding of the role of specific AT depots in the pathogenesis of obesity-associated metabolic diseases. In this abstract, we describe the adaptation of a whole body fat-water MR imaging acquisition and automated analysis pipeline, initially validated in human volunteers, for whole-body FWI in dogs. We demonstrate the utility of this pipeline by following the changes in lean and AT volume in dogs placed on an obesogenic high-fat, high-fructose diet known to increase insulin.