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Abstract #3010

High-Resolution Interstitial MR Lymphography for the Diagnosis of Sentinel Lymph Nodes: Inhomogeneous Distribution of SPIO within Non-Malignant Lymph Nodes

Daisuke Suzuki1,2, Masayuki Yamaguchi1, Toshihiro Furuta1,3, Kohki Yoshikawa2, Hirofumi Fujii1

1Functional Imaging Division, National Cancer Center Hospital East, Kashiwa, Chiba, Japan; 2Graduate Division of Health Sciences, Komazawa University, Setagaya, Tokyo, Japan; 3Department of Radiology, the Tokyo University Hospital, Tokyo, Japan

Since the presence of sentinel lymph nodes (SLNs) metastasis predicts a poor prognosis, the diagnosis of SLN metastasis is clinically important. MR lymphography by means of the interstitial administration of superparamagnetic iron oxide (SPIO) is one of the techniques that can sensitively detect SLNs based on the signal reduction by SPIO trapped by macrophages. To our knowledge, the intra-lymph node distribution of subcutaneously administered SPIO has not been fully understood. In this study, we demonstrated the inhomogeneous distribution of interstitially administered SPIO within regional lymph nodes of mice using high-resolution MRI and Prussian blue-stained specimens