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Abstract #3028

Non-Linear Image Registration of 3He Lung Diffusion MRI Acquired at Different Inflation States, Exemplified by Alveolar Ventilation Maps

Torsten Dorniok1, Peter Magnusson1, Frederik Hengstenberg1,2, Sergei Karpuk3, Jorgen Vestbo2, Per keson1, Lise Vejby Sgaard1

1Danish Research Centre for Magnetic Resonance, Copenhagen University Hospital, Hvidovre, Denmark; 2Department of Cardiology & Respiratory Medicine, Copenhagen University Hospital, Hvidovre, Denmark; 3Institute of Physics, University of Mainz, Mainz, Germany

A non-linear image registration method was used to co-register hyperpolarized 3He diffusion MRI data acquired at different stages of inflation. The method was validated using synthetic data and data from healthy volunteers. ADC values in the original and registered maps were compared regionally to assess if the transformation had any considerable effect on the values.