Abstract #3029

Functional Mapping of Regional Airway Obstruction & Gas Trapping in 3D using Dynamic HP He-3 MRI

Jionghan Dai¹, Eric T. Peterson², James H. Holmes³, Robert V. Cadman¹, Ronald L. Sorkness⁴, Sean B. Fain^1,5

¹Medical Physics, University of Wisconsin - Madison, Madison, WI, United States; ²Biomedical Engineering, University of Wisconsin - Madison, Madison, WI, United States; ³Global Applied Science Laboratory, GE Healthcare, Madison, WI, United States; ⁴pharmacy, University of Wisconsin - Madison, Madison, WI, United States; ⁵Radiology, University of Wisconsin - Madison, Madison, WI, United States

Noble gas MRI enables high contrast to noise dynamic imaging during respiratory maneuvers. A model of gas in-flow using linear system theory to deconvolve the dispersion at the trachea provides maps that are analogous to gas flow, while washout delay during forced exhalation provides maps of gas trapping. In this work the feasibility of these modeling approaches is evaluated in adults and children with known obstructive lung disease.