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Abstract #3037

Accelerated Whole-Lung Specific Ventilation Imaging in Large Species with Hyperpolarized Gas MRI

Kiarash Emami1, Hooman Hamedani1, Yinan Xu1, Stephen J. Kadlecek1, Yi Xin1, Puttisarn Mongkolwisetwara1, Harrila Profka2, Masaru Ishii3, Rahim R. Rizi1

1Radiology, University of Pennsylvania, Philadelphia, PA, United States; 2Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States; 3OtolaryngologyHead & Neck Surgery, Johns Hopkins University, Baltimore, MD, United States

The accelerated acquisition scheme for imaging specific ventilation effectively reduced the total imaging time by a factor of two as implemented in mechanically ventilated Yorkshire pigs. In addition to retaining the breathing pattern closer to normal conditions, this technique is less sensitive to the accumulative RF effect, as well as O2-induced depolarization of 3He, which collectively improve the accuracy of r measurements, and encourages transition to voluntarily breathing human subjects.