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Abstract #3039

Detection of Pulmonary Ischemia using the Oxygen Sensitivity of Hyperpolarized Helium MRI in a Rodent Model of Pulmonary Embolism

Ronn P. Walvick1,2, Austin L. Reno2, Mathew J. Gounis2, Mitchell S. Albert2

1Radiology, New York University Langone Medical Center, New York, NY, United States; 2Radiology, University of Massachusetts Medical School, Worcester, MA, United States

Synopsis: In this work, we present data on the application of the measurement of measuring the time course of the partial pressure of oxygen in the lungs using hyperpolarized helium to detect ischemia in a novel rodent model of pulmonary ischemia. We show that both the initial partial pressure of oxygen is higher, and oxygen uptake rate in the ischemic lung is lower, in the ischemic then in the contralateral lung of embolized animals, and in both lungs of control animals. This work may be useful for the non-invasive evaluation of experimental treatment options for pulmonary embolism.