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Abstract #3040

Free vs. Forced : Gas Transport Differences in 3He MRI Dynamic Ventilation Measurements of Lungs Induced by Gas Mixture Application Regime.

Maxim Terekhov1, Manuela Gueldner2, Klaus Gast3, Julien Rivoire1, Ursula Wolf3, Janet Friedrich1, Sergei Karpuk2, Zahir Salhi2, Laura Maria Schreiber1

1Department of Diagnostic & Interventional Radiology. Section of Medical Physics, Johannes Gutenberg University Medical Center Mainz, Mainz, Germany; 2Institute of Physics, Johannes Gutenberg University Mainz, 3Department of Diagnostic & Interventional Radiology, Johannes Gutenberg University Medical Center Mainz, Mainz, Germany

Dynamic ventilation (DV) of lung measured with 3He MRI is an efficient tool to visualize the intrapulmonary gas inflow. In current work we performed comparison 3He application with two different form of gas bolus: short bolus delivered by Application Unit (AU) in Free-Breathing mode and Forced Inspiration from Tedlar bag (TB) via fine tube with high resistance and prolonged bolus shape. The discrepancy between application modes was considered in terms of first orders Linear Transfer Function. The results show that TB-application changes significantly the gas transport in parenchyma and higher order derivations of input bolus function should be accounted.