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Abstract #3051

Dynamic Contrast-Enhanced Magnetic Resonance Imaging to Assess Desmoid Tumours in Familial Adenomatous Polyposis

Santosh Bhandari1, N. Jane Taylor2, Ashish Sinha1, J. James Stirling2, Ian C. Simcock2, Arun Gupta1, Robin K. S. Phillips1, Susan K. Clark1, Vicky J. Goh2

1Polyposis Registry, St Marks Hospital, London, United Kingdom; 2Paul Strickland Scanner Centre, Mount Vernon Hospital, Northwood, Middlesex HA6 2RN, United Kingdom

Familial adenomatous polyposis (FAP) is an autosomal dominant hereditary condition characterised by multiple colonic polyps at an early age, which if left untreated become cancerous. Extracolonic manifestations are now the leading cause of death following prophylactic colectomy. Up to a quarter of patients will develop desmoid tumours, arising from the musculo-aponeurotic tissues of which about 10% will grow relentlessly, resulting in death. Outcome cannot be reliably predicted from histologic findings. DCE-MRI was performed on desmoid tumours to assess their vascularisation and to explore if it is possible to use it to predict aggressive phenotypes.