Cynthia Menard1,2, Douglas Iupati1, Jenny Lee1, Anna Simeonov1, Jessy Abed1, Julia Publicover1, Peter Chung1, Andrew Bayley1, Charles Catton1, Michael Milosevic1, Robert Bristow1, Gerard Morton3, Padraig Warde1, Kristy Brock1, Masoom Haider3
1Princess Margaret Hospital, Toronto, ON, Canada; 2Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada; 3Odette Cancer Center
We evaluated the performance of MRI (plus/minus guided biopsy) in delineating tumor boundaries for focal salvage therapy of prostate cancer recurrence after external beam radiotherapy. Twenty-three patients were enrolled and received an integrated multiparametric diagnostic and interventional biopsy procedure. MRI alone was not sufficiently accurate to define boundaries for tumor-targeted salvage even with addition of an uncertainty margin. MRI-guided biopsy improved both detection and delineation accuracy for recurrent tumor regions, and changed salvage therapy planning in the majority of patients.