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Abstract #3075

Reduced Field-of-View Diffusion-Weighted Imaging in Patients with Invasive Breast Cancer

Lisa Singer1, Lisa J. Wilmes1, Emine U. Saritas2,3, Ajit Shankaranarayanan4, Evelyn Proctor1, Dorota Wisner1, Belinda Chang1, Bonnie N. Joe1, Dwight G. Nishimura3, Nola M. Hylton1

1Radiology & Biomedical Imaging, UCSF, San Francisco, CA, United States; 2Department of Bioengineering, UC Berkeley, Berkeley, CA, United States; 3Department of Electrical Engineering, Stanford University, Stanford, CA, United States; 4Applied Science Laboratory, GE Healthcare, Menlo Park, CA, United States

Current diffusion-weighted MRI (DW-MRI) sequences used in the breast are often limited in spatial resolution. A reduced field-of-view (rFOV) DW-MRI sequence providing high in-plane resolution was optimized for imaging breast tumors and evaluated against a standard FOV DW-MRI sequence in patients with invasive breast cancer. Quantitative analysis found similar mean tumor apparent diffusion coefficient (ADC) values for both sequences; however, significant differences were found in parameters related to the tumor ADC distribution. Qualitative analysis suggested that tumor depiction on rFOV was improved. Larger studies comparing the ability of rFOV and standard FOV parameters to predict clinical outcomes are needed.