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Abstract #3100

In Vivo Quantitative Proton MR Spectroscopy to Characterize Morphological Pattern of MR Enhancements in Breast Cancer

Hyeon-Man Baek1, Jeon-Hor Chen2, Orhan Nalcioglu2, Min-Ying Su2

1Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, United States; 2Tu & Yuen Center for Functional Onco-Imaging, UC Irvine, Irvine, CA, United States

We reported a larger series study to further investigate if the tCho SNR, tCho concentration, and lipids ratio (e.g., CH2 at 1.3 ppm/CH3 at 0.9 ppm) levels show difference between mass and non-mass type breast cancers. Metabolite basis set signals (e.g., tCho, H2O, and Lipids) were simulated in SIMULATION in jMRUI software (e.g., S = S0 ~ exp(-t-(t)2) ~ exp(i(2ft+0)) and quantified with QUEST. There was significant difference in tCho SNR level between mass-type and non-mass-type groups (p = 0.035). However, no significant group differences were observed in tCho concentration and lipids ratio of 1.3/0.9 ppm (p = 0.461 and 0.242), respectively. This result reflects that tCho SNR measured by 1H-MRS may be a good indicator to distinguish between different tumor morphologies (mass and non-mass).