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Abstract #3101

Using Paired Tissue & Serum Samples to Characterize Human Lung Cancer Metabolomics with Ex Vivo 1H HRMAS MRS.

Elita DeFeo1, Isabel Dittmann, Yannick Berker, Li Su2, Eugene Mark, David Christiani2, Leo L. Cheng3

1Pathology, Massachusetts General Hospital, Charlestown, MA, United States; 2Environmental Health, Harvard School of Public Health; 3Radiology, Pathology, Massachusetts General Hospital

Despite lung cancer being the primary cause of cancer related death in both men and women in the United States, there is no early screening tool available to the general public. Due to the high costs and the radiation exposure of CT or PET, these technologies are not feasible as screening tools. Clinicians desperately need a new diagnostic tool to provide biochemical information that is essential for making early diagnoses and subsequent treatment decisions. In this study we are assessing the matched tissue and sera metabolomic profiles of lung cancer patients in hopes of discovering serum lung cancer metabolomic profiles that can provide patient triages for further tests.