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Abstract #3109

Effect of Anesthesia on Tumor Vascular Permeability Measurements by DCE-MRI

Wenlian Zhu1, Yoshinori Kato1, Dmitri Artemov1

1The Russell H. Morgan Department of Radiology & Radiological Science, Johns Hopkins University, Baltimore, MD, United States

Anesthesia is an essential and yet often overlooked component of preclinical DCE-MRI study. The goal of this study is to investigate whether anesthesia method has any effect on the tumor vascular permeability measurements by DCE-MRI with a macromolecular contrast agent, albumin-(DTPA-Gd) in human breast cancer MCF-7 mouse xenografts. Preliminary results from mice anesthetized by isoflurane alone, and a combination of ketamine/acepromazine induction and isoflurane maintenance are reported here.