Kathleen E. Chaffee1, Jeff R. Anderson1, Joshua S. Shimony1, G. Larry Bretthorst1, Joseph J. H. Ackerman1, Joel R. Garbow1
Accurate, non-invasive determination of tumor boundaries remains a significant challenge for neurosurgeons, with important implications for patient management. MR contrast enhancement, which reflects the breakdown of the blood brain barrier, often serves as a surrogate marker for actively growing tumor. Here we utilize in vivo LAIF-DSC-derived CBV maps as a marker for delineating tumor margins in murine models of glioma. The LAIF-DSC method permits the calculation of perfusion-based parametric maps without requiring independent measurement of an arterial input function. Tumor margins, estimated by histogram analysis and thresholding of the CBV parametric maps, correlate well with histology.