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Abstract #3145

Lipid Profile of Distinct Areas of Astrocytic Brain Tumors

Frauke Nehen1, Laura Columbano2, Rudolf Fahlbusch2, Dieter Leibfritz1

1Institute of Organic Chemistry, University of Bremen, Bremen, Germany; 2International Neuroscience Institute Hannover, Hannover, Germany

Changes of the lipid profile of distinct localisations of high grade astrocytic tumours were analyzed with high resolution 1 H-NMR-spectroscopy. Extracts of active tumor core, tumor margin and more distant tumor margin differ significantly in their content of phosphatidylcholines, plasmalogens, triglycerides and cholesteryl esters. Solid phase extraction revealed a modified fatty acid composition in the tumor core. In addition, galactosyl cerebrosides and dolichols are metabolic discriminators.