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Abstract #3147

Metabolic Signatures in Histopathologically Proven Gallbladder Carcinoma Tissues by Hrmas Nmr Spectroscopy

Santosh Kumar Bharti1, Raja Roy1, Anu Behari2, Vinay K. Kapoor2, C. L. Khetrapal1

1CBMR, Centre of Biomedical Magneetic Resonance, Lucknow, Uttar Pradesh, India; 2Dept. of Surgical Gastroenterology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India

The HRMAS NMR spectroscopic studies have been performed on gallbladder tissues specimens for the first time. A total number of 83 tissue specimens were analysed from 83 patients under going cholecystectomy. The proton NMR metabolic profile clearly distinguishes between the benign chronic cholecystits, xanthogranulomatous cholecystitis and malignant gallbladder tissues. The OPLS-DA, multivariate analysis provided correct classification of the tissues types. The investigation demonstrates the potential of HRMAS NMR for tissues metabotyping.