Abstract #3157

Assessment of Metastatic Potential of 67NR and 4T1 Tumors with Selective Multiple-Quantum Coherence Transfer

Asif Rizwan¹, Inna Serganova², Xiaohui Ni¹, Sunitha Thakur^1,3, Ronald Blasberg^2,3, Jason Koutcher^1,4

¹Medical Physics, Memorial Sloan-Kettering Cancer Center, New York, NY, United States; ²Neurology, Memorial Sloan-Kettering Cancer Center, New York, NY, United States; ³Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, United States; ⁴Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, United States

Metabolic changes in primary tumors are recognized to have a significant impact on the development of metastatic phenotypes. The accumulation of lactate in tumors is associated with aerobic glycolysis. The objective of this study was to compare lactate production in non-metastatic (67NR) and metastatic (4T1) orthotopic implanted murine breast tumors. The spectra are acquired using the selective multiple-quantum coherence transfer (SelMQC) sequence. The 4T1 tumors show a high level of lactate at the early stage of growth while 67NR tumors have barely detectable lactate signal. These results show that lactate can be used as a prognostic marker for tumor metastasis