Sanjay Annarao1, Ku Thomas2, Nagavarakishore Pillarsetty, Jason Koutcher1,2, Sunitha Thakur1,2
1Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY, United States; 2Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, United States
Using SS-SelMQC editing sequence, 2-3 fold increase in the Lac signal to noise is observed when compared to conventional single shot editing method. Absolute quantification of Lac requires correction factors due to J-coupling evolution, molecular diffusion, as well as T1 and T2 relaxation factors. Though we can calculate the effects of J-couplings and molecular diffusion effects, one needs to measure T1 and T2 for absolute quantification. Hence we report a modified T1 and T2 variants of SS-SelMQC sequence to measure Lac T1 and T2 values with increased signal-to-noise. T1 and T2 were measured using phantoms and in-vivo mice breast tumors.