In Vivo Lactate T1 & T2 Relaxation Measurements in ER-Positive Breast Tumors using SS-SelMQC Editing Sequence

Sanjay Annarao¹, Ku Thomas², Nagavarakishore Pillarsetty, Jason Koutcher^1,2, Sunitha Thakur^1,2

Using SS-SelMQC editing sequence, 2-3 fold increase in the Lac signal to noise is observed when compared to conventional single shot editing method. Absolute quantification of Lac requires correction factors due to J-coupling evolution, molecular diffusion, as well as T₁ and T₂ relaxation factors. Though we can calculate the effects of J-couplings and molecular diffusion effects, one needs to measure T₁ and T₂ for absolute quantification. Hence we report a modified T₁ and T₂ variants of SS-SelMQC sequence to measure Lac T₁ and T₂ values with increased signal-to-noise. T₁ and T₂ were measured using phantoms and in-vivo mice breast tumors.