Abstract #3159

Suppression of Peritumoral Edema for Improved Demarcation of Brain Tumor Lesion with T1 Over T2 (T1/T2) Mapping

Jerry S. Cheung¹, Enfeng Wang¹, Giulia Fulci², Phillip Zhe Sun¹

¹Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, MGH & Harvard Medical School, Charlestown, MA 02129, United States; ²Molecular Neuro-oncology Laboratories, Center for Molecular Imaging, MGH & Harvard Medical School, Boston, MA 02124, United States

T₁ and T₂ MRI are widely used MRI parameters in monitoring tumor progression and treatment response, yet unambiguous demarcation of tumor from peritumoral edema is often difficult due to diffuse tumor boundary. Given that both T₁ and T₂ of tumor and edema alter to different extent, we postulate that T₁ over T₂ (TOT) map may augment conventional relaxation time imaging. Our data showed that T₁/T₂ better depicted brain tumor region by suppressing signal from peritumoral edema and CSF, in good agreement with Gadolinium-enhanced MRI.