Masaya Takahashi1, Osamu Togao1, Chase W. Kessinger2, Gang Huang2, Ivan Dimitrov1, A. Dean Sherry1, Jinming Gao2
1Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, United States; 2Simmons Comprehensive Cancer Center, UT Southwestern Medical Center, Dallas, TX, United States
Amide proton transfer (APT) imaging is one of the chemical exchange saturation transfer (CEST) imaging methods which images the exchange between protons of free tissue water and the amide groups (-NH) of endogenous mobile proteins and peptides. Previous work suggested that the ability of APT imaging for characterization of the tumoral grade in the brain tumor. In this study, we tested the feasibility of APT imaging of lung cancer and investigated whether the method characterizes the tumoral types in an orthotopic mouse model.