Abstract #3164

Predicting Glioma Response to Radiotherapy with Amide Proton Transfer (APT) MRI

Jinyuan Zhou^1,2, Silun Wang¹, Betty Tyler³, Rachel Grossman³, Erik Tryggestad⁴, Eric Ford⁴, Michael Armour⁴, Kun Yan¹, Bachchu Lal⁵, Peter C. M. van Zijl^1,2, John Laterra⁵

¹Department of Radiology, Johns Hopkins University, Baltimore, MD, United States; ²F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States; ³Department of Neurosurgery, Johns Hopkins University, Baltimore, MD, United States; ⁴Department of Radiation Oncology, Johns Hopkins University, Baltimore, MD, United States; ⁵Department of Neurology, Kennedy Krieger Institute, Baltimore, MD, United States

We applied APT imaging to U87MG tumor-bearing rats that were treated with radiation therapy (40 Gy). It was found that the APT signal in the radiated tumor significantly decreased after treatment. Our results show the potential of the APT-MRI signal as a biomarker that can greatly improve the value of MRI in the differentiation between viable tumor and radiation necrosis, and in the early prediction of treatment response in brain tumors.