Mary E. Loveless1,2, Deborah Lawson3,
Michael Collins3, Corinne Reimer3, Dennis Huszar3,
Jane Halliday4, John C. Waterton4, John C. Gore2,
Thomas E. Yankeelov2
1Biomedical Engineering,
Vanderbilt University, Nashville, TN, United States; 2Institute of
Imaging Science, Vanderbilt University, Nashville, TN, United States; 3Cancer
Bioscience, AstraZeneca, Boston, MA, United States; 4Translational
Sciences: Imaging, AstraZeneca, Macclesfield, Cheshire, United Kingdom
ADC maps obtained from DW-MRI and the fraction of extravascular-extracellular space (ve) derived from DCE-MRI analysis have been shown to correlate with cellularity in tumors; thus, maps of ADC and ve should be directly related. The goal of this study is to assess the quantitative relationship between these parameters in a mouse tumor model using two treatment regimens. This study shows that both ADC and ve have significant positive correlation with the extracellular space within the tumor. However, ve is hugely overestimated compared to its histological counterpart, indicating there are other factors that influence these imaging parameters, specifically ve.
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