Abstract #3228

Histological Correlation with MRI Findings to Monitor Gene Therapy in an In Vivo Equine Model

Maria Isabel Menendez^1,2, Daniel J. Clark¹, Michelle Carlton³, David C. Flanigan⁴, Guang Jia¹, Steffen Sammet, Steven Weisbrode⁵, Alicia L. Bertone⁶, Michael V. Knopp

¹Radiology, OSU Imaging Core Lab Wright Center of Innovation in Biomedical Imaging, the Ohio State University, Columbus, OH, United States; ²Clinical Veterinary Sciences, College of Veterinary Medicine, Columbus, OH, United States; ³Radiology, Wright Center of Innovation in Biomedical Imaging, the Ohio State University; ⁴Orthopedics, the Ohio State University Medical Center, Columbus, OH, United States; ⁵Veterinary Biosciences, College of Veterinary Medicine, the Ohio State University, Columbus, OH; ⁶Veterinary Clinical Sciences, College of Veterinary Medicine, the Ohio State University, Columbus, OH

Using MRI as a serial non-invasive technique to evaluate healing of surgically created large osteochondral defects in a weight-bearing femoral condyle in response to percutaneous direct injection of adenoviral (Ad) vectors containing coding regions for either human bone morphogenetic proteins 2 (BMP-2) or -6.