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Abstract #3228

Histological Correlation with MRI Findings to Monitor Gene Therapy in an In Vivo Equine Model

Maria Isabel Menendez1,2, Daniel J. Clark1, Michelle Carlton3, David C. Flanigan4, Guang Jia1, Steffen Sammet, Steven Weisbrode5, Alicia L. Bertone6, Michael V. Knopp

1Radiology, OSU Imaging Core Lab Wright Center of Innovation in Biomedical Imaging, the Ohio State University, Columbus, OH, United States; 2Clinical Veterinary Sciences, College of Veterinary Medicine, Columbus, OH, United States; 3Radiology, Wright Center of Innovation in Biomedical Imaging, the Ohio State University; 4Orthopedics, the Ohio State University Medical Center, Columbus, OH, United States; 5Veterinary Biosciences, College of Veterinary Medicine, the Ohio State University, Columbus, OH; 6Veterinary Clinical Sciences, College of Veterinary Medicine, the Ohio State University, Columbus, OH


Using MRI as a serial non-invasive technique to evaluate healing of surgically created large osteochondral defects in a weight-bearing femoral condyle in response to percutaneous direct injection of adenoviral (Ad) vectors containing coding regions for either human bone morphogenetic proteins 2 (BMP-2) or -6.