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Abstract #3241

Assessment of Mechanical Properties of Isolated Intervertebral Discs using Quantitative Magnetic Resonance Imaging

Delphine Pri1,2, Maximilien Recuerda1,3, Guillaume Gilbert4, Gilles Beaudoin5

1Mechanical Engineering, Ecole Polytechnique de Montral, Montral, Qubec, Canada; 2Research Center, CHU Sainte-Justine, Montral, Qubec, Canada; 3Reserach Center, CHU Sainte-Justine, Montral, Qubec, Canada; 4Philips Healthcare, Montral, Qubec, Canada; 5Physics & Biomedical Engineering, CHUM Notre Dame, Montral, Qubec, Canada

We hypothesed that the compressive modulus and hydraulic permeability of the intervertebral disc can be explained by a combination of MRI parameters. Mechanical properties from unconfined compression tests, confined compression tests and direct measurements of permeability, and MRI properties from quantitative T1, T2, ADC, FA and MT acquisitions were evaluated on in-situ and digested bovine isolated discs. Relationships were found between axial or radial hydraulic permeability and quantitative MRI parameters. The changes induced by the trypsin treatment were detected by both mechanical tests and quantitative MRI. Thus the relationships found between permeability and MRI parameters are valid for both groups.