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Abstract #3268

Assessment of Changes in Regional Distribution of Skeletal Muscle Adipose Tissue in Type 2 Diabetes using Quantitative IDEAL Gradient Echo Imaging

Dimitrios C. Karampinos1, Thomas Baum1, Lorenzo Nardo1, Julio Carballido-Gamio1, Paran S. Yap1, Huanzhou Yu2, Ann Shimakawa2, Thomas M. Link1, Sharmila Majumdar1

1Department of Radiology & Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States; 2Global Applied Science Laboratory, GE Healthcare, Menlo Park, CA, United States

Changes in adipose tissue compartmentalization within skeletal muscle have been observed in patients with type 2 diabetes. Segmentation of T1-weighted images has been traditionally used to characterize these changes with significant limitations in quantifying fat content alterations in localized muscle anatomical regions. Quantitative chemical shift-based water/fat separation, like IDEAL gradient echo imaging, enables fat quantification with the spatial resolution of conventional imaging. In the present study, quantitative IDEAL is applied in a study of 46 post-menopausal women to investigate changes in regional distribution of calf muscle adipose tissue between controls and patients with type 2 diabetes.