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Abstract #3269

Diffusion Tensor Imaging of Acute Muscular Injury in Normal & Dystrophic Mice

Alan B. McMillan1, Da Shi1, Su Xu1, R. M. Lovering2

1Diagnostic Radiology & Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD, United States; 2University of Maryland School of Medicine, Orthopaedics, Baltimore, MD, United States

This work investigates diffusion tensor imaging (DTI) and T2 parameter mapping in acute muscle injury of normal and dystrophic mice. Dystrophic mice experienced a force loss that was 2x greater than normal, indicating a more significant injury. Consistent with post-injury edema, significant increases in T2 are observed in proximal sections of the tibialis anterior (TA). However, significant changes in DTI parameters are seen in both the middle and proximal sections of the TA, suggesting that DTI may be a more sensitive marker of acute skeletal muscle injury.