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Abstract #3304

Normal Local Pulse Wave Velocity Predicts Absence of Local Aorta Diameter Growth in Marfan Syndrome: A Comprehensive MRI-Approach

Jos J. M. Westenberg1, Patrick J. H. de Koning1, Pieter J. van Den Boogaard1, Dennis Hendriksen1, Johan H. C. Reiber1, Albert de Roos1, Rob J. van Der Geest1

1Radiology, Leiden University Medical Center, Leiden, ZH, Netherlands

In a comprehensive MRI-approach, patients with Marfan syndrome are evaluated at baseline and at two year follow up. Pulse wave velocity, assessed from two-directional velocity-encoded MRI, is locally assessed in the aorta and compared with local aortic diameter growth, assessed from contrast-enhanced MR angiography of the aorta. With this new imaging tool, normal local aortic pulse wave velocity assessed with two-directional velocity-encoded MRI predicts in 89% of the cases absence of aortic diameter growth in patients with Marfan syndrome after two years follow up.