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Abstract #3339

Optimization of the First-Order Gradient Moment for Flow-Sensitive Dephasing Magnetization-Prepared 3D Noncontrast MRA

Zhaoyang Fan1,2, Xiangzhi Zhou2, Xiaoming Bi3, Sven Zuehlsdorff3, Rohan Dharmakumar2,4, James Carr2, Debiao Li2,4

1Cedars-Sinai Medical Center , Los Angeles, CA, United States; 2Northwestern University, Chicago, IL, United States; 3Siemens Healthcare, Chicago, IL, United States; 4Cedars-Sinai Medical Center, Los Angeles, CA, United States

Flow sensitization imparted by the flow-sensitive dephasing (FSD) preparation is essential for FSD-prepared noncontrast MRA, and its strength can be measured by the first-order gradient moment, m1. Incomplete delineation of arterial segments may result from a suboptimal m1. The optimal m1, however, is subject and artery specific. The aim of this work was to systematically investigate the utility of a 2D m1-scouting method for improving imaging quality of 3D FSD MRA. From 10 healthy subjects and 1 patient, significant increases in artery SNR and artery-vein CNR on MRAs were obtained using this optimization procedure, which potentially help enhance diagnostic confidence.