Ziheng Zhang1, Peter B. Brown1, Donald P. Dione2, Albert J. Sinusas2, Smita Sampath1
1Department of Diagnositc Radiology, Yale University, School of Medicine, New Haven, CT, United States; 2Section of Cardiovascular Medicine, Yale University, School of Medicine, New Haven, CT, United States
Our goal is to evaluate the future application of the SPAMM-PAV (Spatial Modulation of Magnetization with Polarity Alternated Velocity encoding) technique for regional quantification of myocardial material properties through a series of dynamic phantom experiments. We examine the sensitivity to detect edge responses in strain due to sharp changes in material properties, and the sensitivity to detect changes in Youngs modulus of elasticity (Ecc) in gel phantoms with varying stiffness. Results demonstrate 1) using a MICSR reconstruction, we are able to achieve desired strain response, and 2) using SPAMM-PAV combined with a thick-shell constitutive model, we can reliably detect differences in Ecc.