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Abstract #3359

Comparison of Regional Myocardial Function in the Human & the Mouse

Christakis Constantinides1, Daniel Rueckert2, Dimitrios Perperidis1

1Mechanical & Manufacturing Engineering, University of Cyprus, Nicosia, Cyprus; 2Imperial College London, London, United Kingdom

This work quantifies and compares regional and global cardiac performance in humans and mice. Such effort attempts to provide evidence to validate the hypothesis of functional scaling from mouse to human. Its potential clinical significance is in mouse phenotyping for determining myocardial dysfunction, in correlation with perfusion and metabolism.