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Abstract #3439

In Vivo 1H MRS Quantification of Alzheimer Disease in Frontal Hippocampus of Mice with & without Inversion Recovery to Assess the Macromolecular Contribution

Maria Isabel Osorio Garcia1, Diana Sima2, Flemming Ulrich Nielsen3, Tom Dresselaers3, Uwe Himmelreich3, Fred Van Leuven4, Sabine Van Huffel2

1Electrical Engineering - ESAT/SCD, Katholieke Universiteit Leuven, Leuven , Belgium; 2Electrical Engineering - ESAT/SCD, Katholieke Universiteit Leuven, Leuven, Belgium; 3Biomedical Nuclear - Magnetic Resonance Unit, Katholieke Universiteit Leuven, Leuven, Belgium; 4Experimental Genetics Group LEGTEGG, Katholieke Universiteit Leuven, Leuven, Belgium

In this work, we study the metabolite behavior of control and APP.V717I transgenic mice using 1H MRS at 9.4 T in the hippocampus. The time domain quantification method AQSES is use for estimating the metabolite contributions which is able to estimate the background modeling using splines and particularly, individual macromolecular signals have been acquired using inversion recovery and added to the basis set of metabolites used to fit the signals. Results obtained in this study show that there are no significant differences between control and APP mice visible in the available MRS spectra. Furthermore, variability in quantification results indicates that detection of Alzheimer disease in the studied animals using 1H MRS in the hippocampus does not provide the class separation as expected in humans.