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Abstract #3473

Regional Variations in GABA Measured with MEGA-PRESS

Christopher John Evans1, Frederic Boy1, Richard A. E. Edden2, Krish D. Singh1, Petroc Sumner1

1CUBRIC, School of Psychology, Cardiff University, Cardiff, Wales, United Kingdom; 2Russell H. Morgan Department of Radiology & Radiological Science, the Johns Hopkins University, Baltimore, United States

In this work, we report on the regional differences in human GABA levels, measured with MEGA-PRESS. Six regions were studied - anterior cingulate, dorsolateral pre-frontal cortex, inferior frontal gyrus, supplementary motor area, parietal lobe and occipital lobe. There was a significant effect of region and of voxel grey matter fraction on GABA. The measured differences in GABA not attributable solely to differences in the tissue composition across regions.