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Abstract #3474

Motor Control Predicted by GABA Concentration in the Supplimentary Motor Area

Christopher John Evans1, Frederic Boy1, Richard A. E. Edden2,3, Krish D. Singh1, Masud Husain4, Petroc Sumner1

1CUBRIC, School of Psychology, Cardiff University, Cardiff, Wales, United Kingdom; 2Russell H. Morgan Department of Radiology & Radiological Science, the Johns Hopkins University, Baltimore, United States; 3F.M. Kirby Research Center for Functional MRI, Kennedy Krieger Institute, Baltimore, United States; 4UCL Institute of Cognitive Neuroscience & UCL Institute of Neurology, UCL, London, England, United Kingdom

The concentration of inhibitory neurotransmitter GABA has previously been demonstrated to predict participants performance in visual behavioural tasks. Here, we demonstrate that GABA concentration correlates with the performance of participants in a motor task closely associated with behavioural inhibition (the Negative Compatibility Effect, NCE). Individual differences in participants' NCE is explained by differences in participants GABA levels in the supplementary motor area, but not correlated with other brain regions.