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Abstract #3492

Feasibility of Brain MR-Elastography at 1.5 T with a Novel Wave Generator: An Animal Study

Najat Salameh1, Line Souris1, Mathieu Sarracanie1, Ludovic de Rochefort1, Ralph Sinkus2, Luc Darrasse1, Xavier Matre1

1IR4M (UMR 8081), Universit Paris-Sud 11, Orsay, France; 2Inserm U979 - CNRS (UMR 7587), Institut Langevin, Paris, France

Protected by the meninges and the skull, the brain is a challenging organ for Magnetic Resonance Elastography. The challenge persists in rodents despite the smaller dimensions since waves with higher frequencies and lower penetration depth must be accordingly applied to resolve the animal brain structures. In the present study, a new excitation mode, where pressure waves are directly guided into the animal mouth, is proposed. Proof of concept and optimization of the technique were carried out onto gel phantoms at 1.5 T. In vivo rat brain MRE was then performed.