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Abstract #3494

Measurement of Ferret Brain Tissue Stiffness In Vivo using MR Elastography

Yulin V. Chang1, Yuan Aaron Feng1, Erik H. Clayton1, Philip V. Bayly1

1Mechanical Engineering, Washington University, St. Louis, MO, United States

We present our initial experience of measuring brain tissue stiffness in adult ferrets at several frequencies using MR elastography. The average dynamics storage modulus of the ferret brain is measured to be 3.6 1.3 kPa at 400 Hz. Our results suggest that the ferret brain appears to be slightly stiffer than the mouse brain and softer than brain measured at similar frequencies. We also observed frequency dependence of the brain tissue stiffness in the ferret.