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Abstract #3517

Metabolic Kinetics of a Glioma Model using Hyperpolarized 13C Magnetic Resonance Spectroscopic Imaging

Jae Mo Park1,2, Sonal Josan2,3, Taichang Jang4, Milton Merchant4, Yi-Fen Yen5, Ralph Hurd5, Lawrence Recht4, Daniel Spielman1,2, Dirk Mayer2,3

1Department of Electrical Engineering, Stanford University, Stanford, CA, United States; 2Department of Radiology, Stanford University, Stanford, CA, United States; 3SRI International, Menlo Park, CA, United States; 4Department of Neurology & Neurological Sciences, Stanford University, Stanford, CA, United States; 5Global Applied Science Laboratory, GE Healthcare, Menlo Park, CA, United States

In this work, we measured the kinetics of pyruvate metabolism in a glioma brain tumor model using the hyperpolarized 13C technique with a fast spiral CSI sequence, and compared the metabolic kinetics from three different ROIs: brain tumor, normal brain, and vasculature. Robust dynamic curves of Pyr and Lac were achievable repeatedly with 3 seconds of temporal resolution using the variable RF excitation angle on a single slice. The apparent rate constant of Pyr-to-Lac conversion in the brain tumor was noticeably higher than that in the normal brain and the vasculature.