Abstract #3517

Metabolic Kinetics of a Glioma Model using Hyperpolarized 13C Magnetic Resonance Spectroscopic Imaging

Jae Mo Park^1,2, Sonal Josan^2,3, Taichang Jang⁴, Milton Merchant⁴, Yi-Fen Yen⁵, Ralph Hurd⁵, Lawrence Recht⁴, Daniel Spielman^1,2, Dirk Mayer^2,3

¹Department of Electrical Engineering, Stanford University, Stanford, CA, United States; ²Department of Radiology, Stanford University, Stanford, CA, United States; ³SRI International, Menlo Park, CA, United States; ⁴Department of Neurology & Neurological Sciences, Stanford University, Stanford, CA, United States; ⁵Global Applied Science Laboratory, GE Healthcare, Menlo Park, CA, United States

In this work, we measured the kinetics of pyruvate metabolism in a glioma brain tumor model using the hyperpolarized 13C technique with a fast spiral CSI sequence, and compared the metabolic kinetics from three different ROIs: brain tumor, normal brain, and vasculature. Robust dynamic curves of Pyr and Lac were achievable repeatedly with 3 seconds of temporal resolution using the variable RF excitation angle on a single slice. The apparent rate constant of Pyr-to-Lac conversion in the brain tumor was noticeably higher than that in the normal brain and the vasculature.