Jae Mo Park1,2, Sonal Josan2,3,
1Department of Electrical Engineering, Stanford University, Stanford, CA, United States; 2Department of Radiology, Stanford University, Stanford, CA, United States; 3SRI International, Menlo Park, CA, United States; 4Department of Neurology & Neurological Sciences, Stanford University, Stanford, CA, United States; 5Global Applied Science Laboratory, GE Healthcare, Menlo Park, CA, United States
In this work, we measured the kinetics of pyruvate metabolism in a glioma brain tumor model using the hyperpolarized 13C technique with a fast spiral CSI sequence, and compared the metabolic kinetics from three different ROIs: brain tumor, normal brain, and vasculature. Robust dynamic curves of Pyr and Lac were achievable repeatedly with 3 seconds of temporal resolution using the variable RF excitation angle on a single slice. The apparent rate constant of Pyr-to-Lac conversion in the brain tumor was noticeably higher than that in the normal brain and the vasculature.