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Abstract #3518

Construction & Use of a Cryostat for Hyperpolarization Based on a 15 Cm, 4.6T Magnet

Lloyd Lumata1, Richard Martin1, Ashish Jindal2, Zoltan Kovacs1, Craig Malloy1, A. Dean Sherry1, Mark Conradi3, Matthew E. Merritt1

1AIRC, UTSW Medical Center, Dallas, TX, United States; 2UTSW Medical Center, United States; 3Physics, Washington University in St. Louis, St. Louis, MO, United States

In order to produce large volumes of highly polarized imaging agents, a DNP system based on a cryostat placed in an ultra widebore 4.6 T magent has been designed and implemented. The large available space allows a 600 ul sample cup to be used as well as an LN2 shield for the LHe bath. Operating at a 129 GHz ESR frequency and using nitrogen based radicals, samples with sufficient polarization for animal imaging are easily obtained. Total cost of the system was less than $100K, sans the cost of the magnet.