Abstract #3540

In Vivo Localized 15N MRS Detection of Hyperpolarized 15N Labeled Choline in the Rat Brain

Cristina Cudalbu¹, Arnaud Comment², Tian Cheng², Mor Mishkovsky², Rolf Gruetter^2,3

¹Laboratory for Functional & Metabolic Imaging (LIFMET), Ecole Polytechnique Fdrale de Lausanne (EPFL) , Lausanne, Switzerland; ²Laboratory for Functional & Metabolic Imaging (LIFMET), Ecole Polytechnique Fdrale de Lausanne (EPFL), Lausanne, Switzerland; ³Departments of Radiology, Universities of Lausanne & Geneva, Geneva, Switzerland

We acquired localized in vivo hyperpolarized 15N Cho spectra using two different voxel sizes in order to investigate the spatial origin of the 15N Cho signal in the rat brain. In the small voxel where the major blood vessels contribution should be negligible, the in vivo 15N Cho signal was visible for more than 1 min. To our knowledge the in vivo localized detection of hyperpolarized 15N has not been demonstrated to date.