Ilwoo Park1, Simon Hu1, Robert
Bok1, Peter Shin1, Tomoko Ozawa2, C. David
James2, Sabrina M. Ronen1, Daniel B. Vigneron1,3,
Sarah J. Nelson1,3
1Surbeck Laboratory of
Advanced Imaging, Department of Radiology & Biomedical Imaging,
University of California, San Francisco, San Francisco, CA, United States; 2Brain
Tumor Research Center, Department of Neurological Surgery, University of
California, San Francisco, San Francisco, CA, United States; 3Department
of Bioengineering & Therapeutic Sciences, University of California, San
Francisco, San Francisco, CA, United States
We modified a previous compressed sensing scheme and acquired hyperpolarized 13C 3D MRSI data from an orthotopic human xenograft tumor model in rat brain. The 3.72-fold acceleration factor allowed the reliable acquisition of hyperpolarized 13C 3D MRSI data with 4 times better resolution in approximately the same scan time compared to the fully sampled data. The new sequence was applied to evaluate heterogeneous metabolic profiles within the tumor tissue of rats with brain cancer. The results from this study suggest that this technique may be used to differentiate brain tissue with different tumor histology.