Meeting Banner
Abstract #3598

Breathing Gas Calibration for MR CMRO2 Measurements: Comparative Effects on Functional Brain Networks

Dimo Ivanov1, Gabriele Lohmann1, Stefan Kabisch1,2, Ilona Henseler1, Haiko Schloegl1,2, Wolfgang Heinke3, Chloe Hutton4, Robert Turner1

1Max Planck Institute for Human Cognitive & Brain Sciences, Leipzig, Germany; 2Department of Medicine, University Hospital Leipzig, Leipzig, Germany; 3Department of Anestesiology & Intensive Care Therapy, University Hospital Leipzig, Leipzig, Germany; 4Wellcome Trust Centre for Neuroimaging, University College London, London, United Kingdom

Regional changes in the cerebral metabolic rate of oxygen (CMRO2) associated with neural activation can be estimated with MRI using the deoxyhaemoglobin dilution model, whose application requires the calibration of resting-state BOLD signal with a gaseous challenge. In this study we used eigenvector centrality mapping (ECM) to assess whether the brain network connectivity is influenced by commonly used calibration gases. The results suggest that these functional brain networks are only slightly modulated, confirming the applicability of the CMRO2 mapping methodology across most of the brain.