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Abstract #3604

Vascular-Space-Occupancy (VASO) MRI in Human Brain at 7T

Jun Hua1,2, Craig K. Jones1,2, Peter C. M. van Zijl1,2

1Neurosection, Div. of MRI Research, Dept. of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States; 2F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States

VASO-MRI exploits the difference between blood and tissue T1 to blood signal and measure CBV changes using residual tissue signal. At 7T, VASO-MRI faces two challenges: converging blood and tissue T1, and a large positive BOLD effect counteracting the negative VASO change. Off-resonance (>20ppm) MT effects are large in tissue but minimal in blood, which was used to magnify tissue signal while ing blood, and boost SNR by 11233% at 7T. A 3D turbo-field-echo (TFE) sequence with short TE (1.77ms) is employed to minimize the BOLD effect, and provide whole brain coverage (2mm isotropic) for VASO fMRI at 7T.